中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (8): 454-456.doi: 10.12144/zgmfskin201908454

• 论著 • 上一篇    下一篇

慢性自发性荨麻疹患者外周血嗜碱粒细胞CD63和CD203c的表达

孔伟1  曹艳云1  曹秀妮2  徐徉1  蔡海斌1  徐顺明1   

  1. 1上海市浦东新区人民医院皮肤科，上海，201299
    2上海市浦东新区人民医院检验科，上海，201299
  • 出版日期:2019-08-15 发布日期:2019-08-19
  • 通讯作者: 徐顺明，E-mail：13641930667@163.com

Expressions of CD63 and CD203c in serum basophils of chronic spontaneous urticaria patients

KONG Wei1，CAO Yanyun1，CAO Xiuni2，XU Yang1，CAI Haibin1，XU Shunming1   

  1. 1. Department of Dermatology，Shanghai Pudong New Area People’s Hospital，Shanghai 201299，China; 2. Department of Clinical laboratory, Shanghai Pudong New Area People’s Hospital，Shanghai 201299，China
  • Online:2019-08-15 Published:2019-08-19
  • Contact: XU Shunming, E-mail：13641930667@163.com

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摘要： 目的：检测慢性自发性荨麻疹患者中外周血嗜碱粒细胞的活化状态。方法：采用流式细胞技术分别检测慢性自发性荨麻疹患者风团不同持续时间下（A组<2 h，15例；B组12~24 h，15例）、治疗后患者（C组，15例）及健康对照组（D组，15例）外周血嗜碱粒细胞CD63+和CD203c+的表达情况。结果：A、B、C三组外周血嗜碱粒细胞CD63+和CD203c+活化百分率（0.097±0.019，0.072±0.015，0.051±0.012）均高于对照D组（0.007±0.002，P<0.05）。A、B、C三组之间两两比较无显著差异（P>0.05）。结论：活化的嗜碱粒细胞可能参与了慢性自发性荨麻疹的发病过程，但与风团的持续时间无相关性。

关键词: 慢性自发性荨麻疹, 嗜碱粒细胞, CD63, CD203c

Abstract: Objective: To investigate the activation of serum basophils in chronic spontaneous urticaria (CSU) patients. Methods: The expression level of CD63 and CD203c in different time of wheals in CSU patients (group A<2 h，15 cases；group B 12-24 h，15 cases)，after antihistamine therapy (group C，15 cases) and heathy control group (group D,15 cases) was detected by the flow cytometry. Results: The peripheral basophils levels of CSU patients in group A, B and C were 0.097±0.019, 0.072±0.015 and 0.051±0.012, which were higher than that in group D (0.007±0.002，P<0.05). There was no significant  differences between group A, B and C (P>0.05). Conclusion: Activated basophils may be involved in the pathogenesis of CSU, but is associated awith the duration of wheals.

Key words: chronic spontaneous urticaria, basophils, CD63, CD203c