中国麻风皮肤病杂志 ›› 2016, Vol. 32 ›› Issue (2): 85-87.

• 论著 • 上一篇    下一篇

慢性荨麻疹患者血清IL-35和IL-17的检测

郭 敏1 白 莉 2   

  1. 1.山西医科大学第一临床医学院，山西太原 030001 2.山西医科大学第一附属医院，太原，030001
  • 出版日期:2016-02-15 发布日期:2018-12-18
  • 通讯作者: 白莉，E-mail:baili@medmail.com.cn

Detection of serum IL-35 and IL- 17 in the patients with chronic urticaria

GUO Min1, BAI Li2.   

  1. 1.First Clinical Medical college ,Shanxi Medical University, Taiyuan 030001, China 2.The First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Online:2016-02-15 Published:2018-12-18
  • Contact: BAI Li, E-mail: baili@medmail.com.cn

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摘要： 目的: 检测慢性荨麻疹（CU)患者血清中IL-35及IL-17的表达。方法: 病例组60例，根据荨麻疹活动性评分标准评价疾病严重程度，60例健康体检者作为对照。ELISA法检测CU患者与对照血清中IL-35和IL-17的水平，分析其与疾病严重程度的相关性。结果: CU患者组血清IL-35水平为46.73±17.19ng/L明显低于健康对照组的73.78±25.51ng/L（P<0.05)；CU组IL-17表达水平为18.03±8.88ng/L，明显高于对照组的8.46±3.29ng/L（P<0.05)。疾病严重程度评分与IL-35表达水平呈负相关（P<0.05），与IL-17表达水平呈正相关（P<0.05）。结论: IL-35和IL-17可能与CU的发病及严重程度有关。

关键词: 慢性荨麻疹, IL-35, IL-17

Abstract: Objective: To detect the level of IL-35 and IL-17 in the patients with chronic urticaria (CU). Methods: The levels of IL-35 and IL-17 in 60 patients and 60 controls were detected by ELISA and the severity of the patients was assessed by urticaria activity score (UAS) grade standard. The correlation between the level of serum IL-35 and IL-17, and CU severity scores was analyzed. Results: The serum level of IL-35 in the patients was 46.73±17.19ng/L, which was lower than that in the controls (73.78±25.51ng/L). The difference was statistically significant (P < 0.05). The serum level of IL-17 in the patients was18.03±8.88ng/L, which was higher than that in the controls (8.46±3.29 ng/L). The difference was statistically significant (P < 0.05). The CU severity score was negatively correlated to the level of IL-35 and positively to the level of IL-17 (P<0.05). Conclusion: The expression of IL-35 and IL-17 may be involved in the onset and severity of CU.

Key words: chronic curticariaA, IL35, IL17