中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (8): 473-475.doi: 10.12144/zgmfskin201908473

• 论著 • 上一篇    下一篇

血清IL-17和IL-23水平与梅毒病期的相关性

荚琳琳1  季必华2   

  1. 1安徽医科大学附属巢湖医院，巢湖，238000
    2皖南医学院附属弋矶山医院，安徽省芜湖市,241000
  • 出版日期:2019-08-15 发布日期:2019-08-19
  • 通讯作者: 季必华，E-mail: jibihua@ayiyun.com

The relationship of the levels of IL-17 and IL-23 in serum with syphilis

JIA Linlin1, JI Bihua2   

  1. 1. Chaohu Hospital of Anhui Medical University, Chaohu 238000, China; 
    2. Yijishan Hospital of Wannan Medical College, Wuhu 241000, China
  • Online:2019-08-15 Published:2019-08-19
  • Contact: JI Bihua, E-mail: jibihua@ayiyun.com

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摘要： 目的：明确梅毒病期与IL-17和IL-23表达的相关性。方法：采用ELISA法检测收集到的早期梅毒和晚期梅毒患者血清中的IL-17和IL-23水平。结果：共检测18例早期梅毒，18例晚期梅毒及12例正常对照血清。早期梅毒组和晚期梅毒组IL-17分别为（12.723±8.547）ng/L和（18.757±10.607）ng/L，差异无统计学意义（P>0.05）；IL-23水平分别为（9.049±7.301）ng/L和（13.603±7.694）ng/L，差异无统计学意义（P>0.05）。早、晚期梅毒患者IL-17和IL-23水平均高于对照组患者［(5.766±2.153)ng/L和(2.756±1.843)ng/L］（均P<0.05）。结论：梅毒患者血清中的IL-17和IL-23表达水平与病期无相关性。

关键词: 梅毒, IL-17, IL-23

Abstract: Objective: To study the correlation between the level of IL-17 and IL-23 and the different courses of syphilis. Methods: The serum levels of IL-17 and IL-23 in the patients with early syphilis and late syphilis were detected by ELISA. Results: The sera of eighteen patients with early syphilis, 18 patients with late syphilis and 12 healthy controls were collected. The level of IL-17 in the patients with early syphilis and patients with late syphilis were (12.723±8.547)ng/L, (18.757±10.607)ng/L, respectively, with no significant difference (P>0.05)；The level of IL-23 were (9.049±7.301) ng/L, (13.603±7.694)ng/L, respectively, with no significant difference (P>0.05). The level of IL-17 and IL-23 in the early syphilis patients and late syphilis patients were higher than those in healthy controls ［(5.766±2.153)ng/L, (2.756±1.843)ng/L, respectively］ (Ps<0.05). Conclusion: There is no correlation between the level of IL-17 and IL-23 and the courses of TP syphilis.

Key words: syphilis, IL-17, IL-23