中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (3): 148-150.doi: 10.12144/zgmfskin201903148

• 论著 • 上一篇    下一篇

慢性自发性荨麻疹患者血清特异性IgE抗体与自体血清皮肤试验的关系

李光芝1  孙艳茹1  张凤杰1  王振华2   

  1. 1潍坊医学院临床学院，山东潍坊，261053
    2潍坊市人民医院皮肤科，山东潍坊，261041
  • 出版日期:2019-03-15 发布日期:2019-04-04
  • 通讯作者: 王振华，E-mail：wfzcwzh@126.com

Relationship between serum specific IgE antibody and autologous serum skin test in the patients with chronic spontaneous urticaria

LI Guangzhi1, SUN Yanru1, ZHANG Fengjie1, WANG Zhenhua2   

  1. 1. Clinical College of Weifang Medical University, Weifang 261053, Shandong, China; 
    2. Department of Dermatology, Weifang People's Hospital, Weifang 261041, China
  • Online:2019-03-15 Published:2019-04-04
  • Contact: WANG Zhenhua, E-mail: wfzcwzh@126.com

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摘要： 目的：比较慢性自发性荨麻疹(CSU)患者血清特异性IgE抗体检测结果与自体血清皮肤试验(ASST)的关系，探讨ASST的临床意义。方法：对305例慢性自发性荨麻疹患者同时进行血清特异性IgE抗体检测及自体血清皮肤试验(ASST)，对两组的阳性率进行统计分析。结果：305例CSU患者螨虫组合(屋尘螨/粉尘螨)血清特异性IgE抗体与ASST总阳性率分别为47.87%和58.03%，ASST阳性组和阴性组中螨虫组合血清特异性IgE抗体阳性率分别为34.46%和66.41%，两组差异有统计学意义(P<0.05)。ASST阳性程度与对应螨虫、屋尘、狗、大豆、虾血清特异性IgE抗体检测水平呈负相关性(P<0.05)。结论：CSU患者部分常见变应原血清特异性IgE抗体与自体血清皮肤试验结果呈负相关，建议将ASST纳入常规CSU临床检测，ASST阳性的患者可以不进行血清特异性IgE抗体检测。

关键词: 慢性自发性荨麻疹, 血清特异性IgE抗体, 自体血清皮肤试验

Abstract: Objective: To compare the results of serum specific IgE antibody  and autologous serum skin test (ASST) in the patients with chronic spontaneous urticaria (CSU), in order to define the clinical significance of ASST. Methods: The serum specific IgE antibody detection and autologous serum skin test (ASST) were conducted in 305 patients with CSU, and the positive rates of the two grougs were compared. Results: The positive rates of serum specific IgE antibody of mites combination (ermatophagoides pteronyssinus/dermatophagoides farinae) and ASST in 305 patients with CSU were 47.87% and 58.03%,respectively. The positive rates of serum specific IgE antibody of mites combination  in the ASST positive group and ASST negative group were 34.46% and 66.41%, respectively with statistical significance (P<0.05). There was a negative correlation between the positive  of ASST and the serum specific IgE antibody of mites combination, house dust, dog, soybeans, and shrimp, with significant differences (P<0.05). Conclusion: Some serum specific IgE antibodies of common allergens in CSU patients are negatively correlated with the results of ASST. It is suggested that ASST should be included in the routine CSU clinical test and the serum specific IgE antibodied of the patients with ASST positive need not   be detected.

Key words: chronic spontaneous urticaria, serum specific IgE antibody, autologous serum skin test