Abstract: Objective: To assess the efficacy of 1565nm non-ablative fractional laser combined with glucocorticoid in the treatment of hypertrophic scar. Methods: The patients with hypertrophic scar were collected and divided into two groups. The patients in the experimental group were treated with 1565 nm non-ablative fractional laser with energy of 10-70 mJ and energy density of 50~500 J/cm2, combined with local injection of glucocorticoid. The patients in the control group were only treated with local injection of glucocorticoid. The color, texture and thickness of scar were assessed through vancouwer scar scale (VSS). Results: Sixty patients were collected, 30 patients in each group. The total effective rate in the experimental group was 93.4%，which was higher than that in the control group (70%) , with a significant difference (P<0.05). The VASS scores in the experimental group and control group were 2.18 and 3.68, with a significant difference (P<0.05). Conclusion: 1565 nm non-ablative fractional laser combined with glucocorticoid injection in the treatment of hypertrophic scar was more effective than glucocorticoid injection alone.

Key words: hypertrophic scar, glucocorticoid, 1565 nm non ablative fractional laser