Abstract: The clinicopathological data of eccrine poroma (EP) was analyzed in 67 cases including 36 males and 31 females, with a mean age of (51.19±19.17) years old. The lesions were usually located on the palmoplantar (34 patients, 50.7%) and manifested as skin tone, dark brown or burgundy round or circular patches, polypoid erosion or bleeding ulcer lesions. Most patients had no obvious subjective symptoms. The misdiagnosis rate of first diagnosis was 95.5%，most frequently as verruca (18 patients，26.87%), granuloma (10 patients，14.93%), seborrheic keratosis (9 patients，13.43%). Biopsy showed hyperplasia of basal cell and cuboidal cells with ductal differentiation, rounded or oval monomorphic nuclei and scarce cytoplasm. The lesions in all the patients were removed by surgery. Eighteen patients were lost to follow up and 49 were no recurrence after 1 month to 3 years follow up.

Key words: eccrine poroma, clinicopathological, Surgical removal