Abstract:

Objective: To assess the clinical efficacy of carbon-dioxide fractional laser combined with naftifene ketoconazole cream in the treatment of onychomycosis. Methods: The onychomycosis patients from Jan, 2017 to Aug, 2018 were treated with CO₂ fractional laser once every 2 weeks and topical naftifene ketoconazole cream everyday for 16 weeks. The efficacy, fungal clearance rate and side effects of every patients were assessed. Results: Thirty-five patients with 35 nails, including 5 fingernails and 30 were treated. Of 35 nails, 8 were superficial white onychomycosis, 18 were distal and lateral subungual onychomycosis, and 9 were proximal subungual onychomycosis. The efficiency and fungal clearance rate were 54.29% and 74.29% after treatment for 4 times, while the efficiency and fungal clearance rate were 82.89% and 88.57% at the third month after the end of treatment. Conclusion: CO₂ fractional laser combined with naftifene ketoconazole cream is effective and safe in treating onchomycosis.

Key words: CO₂ fractional laser, naftifene ketoconazole, onychomycosis