Abstract: Epidermal growth factor receptor (EGFR) is one kind of receptor tyrosine kinase, which exists in the membrane of almost all epithelial cells and many mesenchymal cells. The imbalance of EGFR pathway may lead to cell proliferation, angiogenesis, apoptosis damage, cell invasion enhancement, and participate in the pathogenesis of skin inflammation and skin tumor. The update of EGFR pathway in the pathogenesis of related skin diseases is reviewed in this paper.

Key words: epidermal growth factor receptor, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase (PI3K)