寻常型天疱疮,桥粒胶蛋白,斑菲素蛋白,乙酰胆碱受体,甲状腺过氧化物酶 ," /> 寻常型天疱疮,桥粒胶蛋白,斑菲素蛋白,乙酰胆碱受体,甲状腺过氧化物酶 ,"/> Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris

China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (5): 324-327.doi: 10.12144/zgmfskin202105324

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Update of non-desmoglein IgG autoantibodies in the pathogenesis of pemphigus vulgaris

XIE Zhimin1,2, SHEN Xuchen1,2, DAI Xiangnong1,2, LI Qingqing1,2, YE Xingdong1,2   

  1. 1 Department of Dermatology, Guangzhou Institute of Dermatology, Guangzhou 510095, China; 2 Institute of Dermatology, Guangzhou Medical University, Guangzhou 510095, China
  • Online:2021-05-15 Published:2021-04-29
  • Contact: YE Xingdong, E-mail: yxingdong@qq.com

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Abstract: The the pathogenesis of pemphigus vulgaris (PV) was associated with autoantibodies against desmosomal cadherin, desmoglein1 (Dsg1) and Dsg3 in previous studies, and now many non-Dsg autoantibodies were reported including desmocollin (Dsc) 1 and Dsc3, plakophilin (PKP) 1 and PKP3, plakoglobin (PG), desmoplakin (DP), acetylcholine receptor (AChR), secretory pathway Ca2+/Mn2+-ATPase isoform 1 (SPCA1), thyroid peroxidase (TPO) and mitochondrial protein. The non-Dsg autoantibodies associated with pathogenesis of PV were reviewed in this paper.

Key words: pemphigus vulgaris, desmocollin, plakophilin, acetylcholine receptor, thyroid peroxidase