Abstract: Objective: To analyze the risk factors of pemphigus vulgaris with acute pulmonary embolism (APE). Methods: The data of 7 patients with pemphigus vulgaris combined with APE from 2012 to 2020 were analyzed (observe group). And 50 pemphigus vulgaris patients without acute pulmonary embolism included as controls. Results: 7 patients had APE from day 3 to day 16 after treated for pemphigus vulgaris. The average age of onset of the patients in the observe group was (57.28±14.24) years old, which was higher than in the control group (47.36±10.49 years) (P＝0.029). Compared with the control group, the incidence rate of bedridden, lung infection, hypertensive and hyperlipidemia were higher in the observe group, with significant differences (Ps<0.05), and the value of serum albumin was lower and the course was shorter, with significant differences (Ps<0.05). Of 7 cases with APE, 5 were cured and 2 improved after treatment for  APE. Conclusion: The incidence of pemphigus vulgaris with acute pulmonary embolism may be related to age, course of disease, stay in bed, pulmonary infection, low albumin, hypertension and hyperlipidemia.

Key words: pemphigus vulgaris, pulmonary embolism, clinical analysis