China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (5): 332-336.doi: 10.12144/zgmfskin202105332

• Reviews • Previous Articles    

Role of HIF-VEGF-Notch signaling pathway in angiogenesis

WANG Meiling, LIU Huaxu   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venerology, Shandong First Medical University, Jinan 250022, China
  • Online:2021-05-15 Published:2021-04-29
  • Contact: LIU Huaxu, E-mail: liueternal@163.com

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Abstract: Angiogenesis is an important branch of vascular system, which plays an important role in physiology and pathology. The complex process of angiogenesis includes many kinds of cytokines, signal pathways, gene regulation. The relationship and role of hypoxia inducible factor-1 α (HIF-1 α), vascular endothelial growth factor (VEGF) and Notch signaling pathway in the angiogenesis are reviewed in this paper.

Key words: angiogenesis, Notch signaling pathway, VEGF, HIF-1α