Abstract: Objective: To detect the blood lipids and sex hormone of post-adolescent female patients with acne and to investigate the relation between the acne and blood lipids, sex hormone. Methods: The level of triglycerides, high-density lipoprotein (HDL), pituitary prolactin, follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone and androstenedion was detected in the post-adolescent female patients with acne vulgaris and healthy controls. Results: 524 post-adolescent female acne patients including 239 mild acne, 207 moderate acne and 78 severe acne, and 50 healthy controls were enrolled. The levels of prolactin, androstenedione and dehydroepiandrosterone sulfate in the patients with mild acne, moderate acne and severe acne were higher than in healthy controls, with significant differences (Ps<0.05). 379 patients didn't suffer from polycystic ovary syndrome, of whom 317 cases had normal level of androstendione and 60 had high level androstendione. Compared with the patients with normal level of androstendione, the levels of prolactin, LH, testosterone, dehydroepiandrosterone sulfate, HDL in the patients with high level androstendione were higher, the level of triglycerides was lower (Ps<0.05). Conclusion: Post-adolescent female acne patients often accompanied by multiple sex hormone abnormalities, especially high level of androgen.

Key words: acne vulgaris, sex hormones, androstendione, blood lipids