Abstract: Objective: To summarize the skin infection related factors, pathogens and drug sensitivity of hospitalized patients with autoimmune bullous disease. Methods: The clinical data of patients with autoimmune bullous disease from 2013 to 2019 were collected, and their infection-related factors, skin infection pathogens, and drug sensitivity tests were retrospectively analyzed. Results: A total of 656 hospitalized patients with autoimmune bullous disease were included, the rate of infection was 74.29%. The infection rate was 39.51% and 31.07% in the patients with hospital stay over 14 days and within 14 days respectively (P＜0.05). The  infection rate was 42.20% and 33.26% in the patients with mucosal involvement and with no mucosal involvement respectively (P＜0.05). The infection rate was 46.43% and 33.08% in the patients with diabetes and with no diabetes respectively (P＜0.05). The main pathogen of skin infections was Staphylococcus aureus (37.68%). There was a high sensitivity for sulfamethoxazole (93.46%), vancomycin (99.35%) and linezolid (100%). Klebsiella pneumoniae was the most common gram-negative bacteria (20.00%). The overall proportion of MRSA, gram-negative bacteria and fungi was increasing year by year. Conclusion: Patients with autoimmune bullous disease are prone to skin infection. The skin infection rate is related to the length of hospital stay, mucosal involvement, and diabetes. The most common pathogen of skin infections is Staphylococcus aureus.

Key words: autoimmune bullous diseases, pemphigus, bullous pemphigoid, infection, Staphylococcus aureus