Abstract: We first proposed the conception of cutaneous amyloidosis pemphigoid and reported a case in this paper. A middle-aged female presented with hypertrophic patches, no blisters, with itching for 17 years on trunk and limbs. Biopsy showed a large number of eosinophilic amorphous substance deposition in dermal papilla and the crystal violet staining was positive. DIF showed the granular deposition of IgG and IgM was found in the basement membrane and dermal papilla, and negitive for C3 and IgA. IIF positivity of antibody IgG was noted with both routine and salt split method. Enzyme-linked immunosorbent assays showed anti BP180 antibody was 0 U/mL and anti BP230 antibody was 169.2 U/mL. 

Key words: amyloidosis pemphigoid, nonbullous pemphigoid, immune fluorescent