China Journal of Leprosy and Skin Diseases ›› 2021, Vol. 37 ›› Issue (10): 633-636.doi: 10.12144/zgmfskin202110633

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Expression of Gsk-3β, CD82 and Axin1 in mammary Paget's disease and extramammary Paget's disease

WEI Liping1, ZHOU Wenwen1, WANG Haomin2, ZHANG Shifa3   

  1. 1 Graduate Training Base of Northern Theater General Hospital of Jinzhou Medical University, Shenyang 110016, China; 2 Graduate Training Base of Northern Theater General Hospital of Dalian Medical University, Shenyang 110016, China; 3 Department of Dermatology, Northeast International Hospital, Shenyang 110623, China
  • Online:2021-10-25 Published:2021-08-31
  • Contact: ZHANG Shifa, E-mail: zhangshifa_1963@126.com

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Abstract: Objective: To detect the expression of Gsk-3β, CD82 and Axin1 in mammary Paget's disease (MPD), extramammary Paget's disease (EMPD) and normal skin tissues by immunohistochemical method.Methods: The expression levels of Gsk-3β, CD82 and Axin1 of lesions in 20 MPD cases, 20 EMPD cases and normal skin in 10 controls were detected by immunohistochemical. Results: The expression of Gsk-3β in MPD and EMPD were 3.39±1.41 and 2.93±1.37, which were significantly lower than that in normal skin (6.50±2.16). The expression of CD82 in MPD and EMPD were 6.05±2.14 and 3.90±1.75, which were significantly lower than that in normal skin (10.68±1.11). The expression of Axin1 in MPD and EMPD were 2.39±1.49 and 2.77±1.64, which were significantly lower than that in normal skin (5.57±1.72). There was no significant difference of the expressions of Gsk-3β, CD82 and Axin1 in lesions of MPD and EMPD (P>0.05). Conclusion: The expression level of Gsk-3β, CD82 and Axin1 are decreased in MPD and EMPD, which may be related to the onset of MPD and EMPD.

Key words: immunohistochemistry, Paget's disease, Gsk-3β, CD82, Axin1