Abstract: Objective: To detect the expression of Axin1, Gsk-3β and CD82 proteins in cutaneous squamous cell carcinoma. Methods: The expression level of Axin1, Gsk-3β and CD82 in 40 cases with cutaneous squamous cell carcinoma (cSCC) and 15 normal skin tissues were detected by immunohistochemistry. Results: The positivity rates of Axin1 in the normal skin, and cSCC lesions with pathological grade I, grade II and grade III were 86.7%, 66.7%, 40.0% and 10.0%, respectively, while the positivity rates of Gsk-3β were 80.0%, 73.3%, 20.0% and 20.0%, The positivity rates of CD8 were 73.3%, 60.0%, 26.7% and 10.0%. There was a positive correlation between the expression level of Axin1 and Gsk-3β in cSCC (r=0.677, P<0.05). Conclusion: The expression of Axin1, Gsk-3β and CD82 in cSCC may be related to the development of CSCC.

Key words: cutaneous squamous cell carcinoma, Axin1, Gsk-3β, CD82, immunohistochemistry