Abstract: The data of eight cases with sebaceous carcinoma from May 2017 to April 2022 were analyzed retrospectively. The results showed 6 tumors were on the eyelid, one on the face, one on the opisthotic skin. The patients were 3 males and 5 females with a median age of 72 years. The clinical feature was a single painless mass and the course of disease ranged from 2 months to 3 years. Recurrence occurred in 2 of the 8 patients, and the recurrent skin lesions were located on the eyelid. Histological examination showed the tumor cells infiltrated in irregular lobules or nodules pattern. Sebaceous gland-like cells with empty cytoplasm were surrounded by the basal-like cells at the periphery of cellular nests. All of the cases were positive for CK, EMA, p63 and AR and had a high Ki-67 index (20%~90%).

Key words: sebaceous carcinoma, pathological features, immunohistochemistry