Abstract: Objective: To determine the effect of hemoperfusion on oxidative stress in children with abdominal Henoch-Schonlein purpura (HSP) and its clinic effects. Methods: The abdominal HSP children were enrolled from January 2020 to January 2021 in our hospital. The patients were divided into the control group and observation group. All the patients were given glucocorticoid, and the patients in the observation group were given additional hemoperfusion. Superoxide dismutase (SOD), malondialdehyde (MDA), TNF-α and IL-6 were detected. Results: A total of 104 cases were collected with 52 in each group. The disappearance time of abdominal pain, bloody stool, rash and hospitalization time in observation group were 3.62±0.57 d, 5.13±0.72 d, 4.53±0.64 d and 16.37±1.85 d respectively, which was shorter than those in control group (5.32±0.84 d, 7.37±1.16 d, 6.65±1.04 d and 19.34±2.26 d,P<0.01). After treatment, the SOD of observation group was significantly higher than that in control group (P<0.01), and MDA, TNF-α, and IL-6 was significantly lower than that in control group (P<0.01). The efficiency rate in observation group was 92.3%, which was significantly higher than that of 80.8% in control group (P<0.05). Conclusion: Hemoperfusion can significantly reduce the oxidative stress and inflammatory reaction of children with severe abdominal HSP, with significant efficacy.

Key words: hemoperfusion, severe abdominal Henoch-Schonlein purpura, children, oxidative stress, inflammatory response