Abstract: A 44-year-old female presented with repeated systemic macular rash for 10 years, aggravated for 1 month. And no improvement was observed after previous treatment with glucocorticoid, traditional Chinese medicine, and vitamins. According to biopsy of labial gland tissue showed 5 lymphatic aggregation dryness combined with other examination of antinuclear antibodies, the diagnosis of Sjogren's syndrome, hyperglobulinemia purpura, and suspected diagnosis of renal tubular acidosis type I was made. After immunoadsorption combined with glucocorticoid and immunosuppressant treatment, the patient was improved.

Key words: immunoadsorption, Sjogren's syndrome, hyperglobulinemia purpura