Abstract: Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) can involve organs such as skin, liver , spleen, and bone marrow, but involvement of the breast has not been reported. Herein, a case is reported and relevant literature reviewed. A 19-year-old female patient presented with recurrent erythema, blood blisters and high fever for 17 years, and right facial swelling for 4 months.  Histopathology of the skin lesion showed a large number of lymphoid cells were infiltrated in the whole dermis, especially around blood vessels, appendages and fat lobules, some of which were plasmacytoid, with mild cell atypia and abnormal mitosis.  Immunohistochemistory showed CD3, CD4,CD8, CD20 and CD45RO were strongly positive. EBER(+). Puncture pathological biopsy of breast tumor: more lymphocyte infiltration was observed in lobules in some areas, EBER (+).  The final diagnosis was hydroa vacciniforme-like lymphoproliferative disorder with breast metastasis. After treatment in the breast surgery department, rheumatology department, and burn surgery department, the patient had an enlarged leg ulcer accompanied by bleeding. And the histopathology of the left leg ulcer showed that transformation of lymphoproliferative disease associated with varicella vesicular disease-like EB virus infection to lymphoma  (extranodal NK/T-cell lymphoma). The patient finally died 19 years after the disease.

Key words: hydroa vacciniforme-like lymphoproliferative disorder, Epstein-Barr virus, breast