A 26-year-old female presented with papules, nodules and pruritus for 3 years. After treated with oral cyclosporin and methylprednisolone, the condition still recurred. After treatment with the JAK inhibitor upatinibthe, the pruritus was controlled and the skin lesions gradually subsided. The condition was not repeated after 4 months follow-up. Dermatology examination showed bean-sized brown and flesh colored nodules distributed on the limbs.