Abstract: As a research hotspot for pemphigus treatment in recent years, biological agents will achieve more accurate targeted treatment strategies and avoid the harm caused by excessive immunosuppression to a large extent for the research and application of iconic inflammatory cells, factors and signal pathways involved in the pathogenesis of pemphigus. This paper reviews the latest research progress of targeted drugs developed for the key targets in the pathogenesis of pemphigus in recent years, and looks forward to more precise targeted therapy, which may bring new prospects for the treatment of pemphigus.

Key words: pemphigus')">pemphigus, targeted treatment, B cell, monoclonal antibodies, T cell