Abstract: A 70-year-old female presented with multiple subcutaneous nodules on her left chest for 2 months. Pathology showed the epidermis atrophic, and the basal cells were vacuolated. The infiltration of mononuclear cells was observed in the superficial dermis, and some cells became nests with unequal amounts of nuclear dust. Immunohistochemistry showed positivity for CD20, CD19, CD79a, MUM -1, CD5, Bcl-2, BCL-6, 10% of the cells were positive for C-MYC, and 80% of the cells were positive for KI-67LI. The patient was diagnosed as Diffuse large B cell lymphoma Phase IV , IPI , 4 scores , involving skin. The patient's condition was improved after 6 cycles of R-CHOP chemotherapy. No recurrence was observed after follow-up for half a year.

Key words: diffuse large B cell lymphoma, skin involvement