Abstract: Objective: To determine the risk factors of female androgenetic alopecia (FAGA). Methods: The data of 225 non-pregnant and non-lactating females with FAGA from January 2017 to June 2022 in the hair clinic of our hospital were retrospectively analyzed. The content of the analysis included clinical manifestations, concomitant diseases, lifestyle habits and laboratory indicators. Results: A retrospective analysis showed that  the disease began at adolescence in 73.78% patients. The width of the hair crack on the frontoparietal, occipital and temporal regions,, were significantly positively correlated with the Sinclair classification (Ps<0.001). The prevalence of vitamin D3 deficiency was high in this population, but there was no significant difference with disease severity, while vitamin B12 deficiency (P=0.003) and elevated triglycerides (P=0.016) were positively correlated with disease severity. At the same time, fatty liver was positive correlation with the severity of disease (P=0.001). Conclusion: The width of the hair crack is positively correlated with the overall severity of alopecia. Fatty liver, decreased vitamin B12 and increased triglyceride may be the related factors of FAGA exacerbation.

Key words: female androgenetic alopecia, temporal hair loss, non-alcoholic fatty liver disease, vitamin D deficiency