Abstract: Objective: To investigate the therapeutic effect of trephine resection, combined with medication injection and pulsed dye laser (PDL) for treating keloid. Methods: Ten keloid patients treated with trephine resection, combined with medication injection(triamcinolone acetonide 5 mL, 5-fluorouracil 0.6 mL, 2% lidocaine 1 mL) and PDL in our hospital from January 2022 to June 2023 were analyzed. Results: The clinical therapy and 12 months follow-up of all patients were completed. The keloid on the operated area were flat and soft, the skin color was close to the normal skin, and the pain and itching were relieved or disappeared. The cure rate and effective rate were 80% and 90%, 90% of the patients were satisfied with the treatment. Conclusions: The combined treatment of trephine resection with drug injection and PDL is a safe and effective treatment for keloid, with higher patient satisfaction.

Key words: keloid, trephine resection, medication injection, 595 pulsed dye laser