Abstract: Objective: To evaluate the efficacy of concentrated growth factors (CGF) in the treatment of leprosy ulcers. Methods: Three patients with lower limb leprosy ulcers (involving a total of 5 wound sites) were treated with CGF. The specific procedure included wound debridement, preparation of CGF gel membrane, and filling of the membrane into the wounds. The growth of granulation tissue in the wounds was observed during the treatment period. Results: On the 5th day of treatment, fresh granulation tissue growth was observed at the wound base. After 2 weeks of treatment, the areas of the 5 ulcers were reduced by 35%, 25%, 30%, 25%, and 35% respectively. After 1 month of treatment, they were reduced by 90%, 80%, 85%, 80%, and 95% respectively. All ulcers achieved complete healing on the 70th day of treatment. During a 1-year follow up, no recurrence of ulcers was observed. Conclusions: Concentrated growth factors are effective in the treatment of leprosy ulcer wounds.

Key words: leprosy, ulcer, concentrated growth factor