Abstract: Objective: To determine the sensitizing drugs to characterize and clinical features of severe drug eruption. Methods: The clinical data of the patients with severe drug eruptions in our department were analyzed retrospectively. Results: Out of 73 patients, the sensitizing drugs in 66 patients were determined (90.41%), including antiepileptics in 24 patients (32.88%), anti-gout drugs in 18 (24.66%), antimicrobial in 12 (16.44%) and antipyretic drugs in 7 (9.59%). accounting for 83.57% of all the sensitizing drugs. Carbamazepine (12.33%) and allopurinol (24.66%) were the most common drugs in single sensitizing drugs. Twenty-nine patients manifested as Stevens-Johnson syndrome, accounting for 39.73% of all the patients. The effective rate of glucocorticoid treatment was 93.15%. Conclusion: The most sensitizing drugs are antiepileptics, anti-gout, antimicrobial and antipyretic drugs. Stevens-Johnson syndrome is the most type of severe drug eruption. Glucocorticoid should be used as the first choice in the treatment of severe drug eruptions.

Key words: severe drug eruption, sensitizing drug