Abstract: Objective: To detection the bacteriological colonization of eczema and assess the efficacy of desonide cream combined with fusidic acid cream in the treatment of infected eczema. Methods: Eighty four patients with eczema were randomly divided into two groups. Patients in group A were treated with desonide cream (twice a day) combined with fusidic acid cream (twice a day), and patients in group B were given desonide cream only (twice a day) for 14 days. Effective rate was assessed after treatment of 7 days and 14 days. Bacterial cultures and drug sensitivity test were performed before treatment. Results: The effective rates after 7 days and 14 days treatment in group A were 71.43% and 88.09% respectively, which were significantly higher than those in group B (42.86% and 69.05). The differences were significant (P=0.008 and P=0.033). The bacteria culture of 45 patients was positive, including 32 isolated of staphylococcus aureus, 10 staphylococcus epidermis, 2 escherichia coli and 1 streptococcus. Conclusion: Eczema usually accompanied with bacterial infection and desonide cream combined with fusidic acid cream is effective in the treatment of infected eczema.

Key words: eczema, bacteriological colonization