Abstract: Skin contains keratinocytes, fibroblasts and melanocytes. Mechanical stress can damage the proliferation, differentiation, migration, cellular morphology and endocrinology of the skin cells. The mechanical stress is affected by the species, magnitude of force, the length of time and the microenvironment of skin cells. The physiological and pathological process of healing of skin wound, scar and hyperpigmentation were also affected by mechanical stress.

Key words: mechanical stress, keratinocyte, dermal fibroblast, melanocyte