Abstract: Objective: To determine the effect of exosome derived from the dendritic cells (DCs) induced by Adenovirus-Suppressor of cytokine signaling1 (Ad-SOCS1) on the psoriasis-like murine models. Methods: The exosomes of murine DCs were infected by Ad-SOCS1. The levels of SOCS1, CD63 and ICAM-1 from exosome were detected by Western Blot. The psoriasis-like murine models were induced by imiquimod (IMQ) and were divided into the DC-exo(s) group and IMQ-group. The mRNA levels of IL-17A, IL-22 and IL-23 in peripheral blood were detected by RT-PCR. Results: SOCS1, ICAM-1 and CD63 proteins in exosomes were detected. The symptoms??of?the psoriasis-like mouse in the?DC-exo(s) group?were better than?that in the control?group. The level of IL-17A and IL-23 mRNA were higher in the DC-exo-S group than that in the control group. There was no significant difference in the IL-22 level between the DC-exo-S group and control group. Conclusions: Exosome from Ad-SOCS1-infected DCs culture can improve the psoriasis-like murine models. The mechanisms may be associated with the inhibition of IL-17A and IL-23. 

Key words: suppressor of cytokine signaling1 (SOCS1), psoriasis, dendritic cells (DCs), exosome, IL-17A