Abstract: A 76 year-old female presented with multiple subcutaneous nodules with skin ulceration on his right lower leg for 2 months. The biopsy featrues of the lesion were accordance with non-Hodgkin's lymph nodes, B cell type, immunophenotype conforms to DLBCL, germinal center source. Immunohistochemistry showed positiveity for CD20 , CD3 and CD10. 80% of the cells were positive for Ki67 and FDC net disappears. Enhanced CT suggested gastric antrum duodenal space-occupying lesions. The biopsy featrues of gastric antrum lesions were accordance with non-Hodgkin B Cellular lymphoma, DLBCL or other highly invasive types. Immunohistochemistry showed positivity for CD20 and Ki67 (90%). The patient was diagnosed as Non-Hodgkin's lymphoma (diffuse large B-cell type) Phase IV IPI, 5 scores, involving skin. The treatment was refused by the family members and the?patient died after?discharged one week.

Key words: Diffuse large B cell lymphoma, skin involvement