Abstract: Human papillomavirus (HPV) is a circular double-stranded DNA virus with phagocytic properties. HPV is classified as high-risk and low-risk types according to the pathogenicity, which can respectively lead to benign hyperplasia and malignant transformation of epithelial cells. E5, E6, E7 and L1 / L2 capsid proteins are generally involved in carcinogenesis and E6 may inhibit the function of PDZ and Daxx protein, E7 protein affect the transcription of a variety of mi-RNA through making the multiple signal pathways disorder and mediates immune escape. E5 protein and L1 / L2 capsid protein can enhance the carcinogenesi of E6 and E7 protein. The update mechanism of HPV -induced skin tumor is reviewed in this paper.

Key words: human papillomavirus, skin neoplasm；mechanism