Abstract: Objective: To assess the efficacy and safety of Yupingfeng powder combined with antihistamines in the treatment of chronic urticarial. Methods: The articles of randomized controlled trials about the Yupingfeng Powder combined with antihistamines for treating chronic urticaria (RCTs) were searched in CNKI, Wanfang database, VIP database, PubMed, EMbase and Cochrane library from the date of establishment of the datebases to November 2017. The data was selected by two reviewers independently. The methodological quality was assessed by Cochrane Handbook. Meta analysis was performed by Review Manager 5.3 software. Results: A total of 15 articles involving 1336 patients were included. The results of Meta analyses showed that compared with the group of antihistamines alone，the effective rate in the group of Yupingfeng Powder combined with antihistamines was higher (P<0.00001), the recurrence rate was lower (P<0.00001), the adverse events was lower (P=0.003). Conclusion: Yupingfeng Powder combined with antihistamines was more effective and safe than antihistamines alone in the treatment of chronic urticarial.

Key words: Yupingfeng powder, antihistamines, chronic urticarial, Meta analysis