Abstract: We report a case of discoid lupus erythematosus (DLE) that was successfully treated with tofacitinib. The patient had a 10-year history of DLE and achieved a favorable response to oral prednisone 20 mg and hydroxychloroquine 200 mg; subsequently, prednisone was gradually tapered and discontinued. Over the past year, the patient’s condition exacerbated, and he refused the re-administration of glucocorticoids. Based on previous literature reports and after obtaining written informed consent from the patient, tofacitinib (5 mg twice daily) combined with topical halometasone cream was administered for treatment. During a 16-month follow-up period, the skin lesions gradually regressed, and no significant adverse reactions were observed throughout the treatment course.

Key words: cutaneous lupus erythematosus, discoid lupus erythematosus, tofacitinib, JAK inhibitor