Abstract: Granular cell tumor (GCT) is a rare benign soft tissue tumor with nonspecific clinical manifestations, leading to frequent misdiagnosis. We retrospectively analyzed the clinical, histopathological and immunohistochemical features of 4 cases of cutaneous GCT diagnosed at Dalian Dermatosis Hospital from January 2020 to January 2025, to improve its recognition and management. All 4 patients were female, aged 35-50 years with a mean age of 42.25 years; the disease course ranged from 1 to 4 years with an average of 2 years. The lesions were located on the vulva, scalp, posterior neck and abdomen, with a mean tumor diameter of approximately 2.5 cm, and 2 cases were accompanied by pain. Histopathology showed that tumor cells were diffusely distributed in sheets, nests or cords, with polygonal or oval cells, small nuclei, and abundant cytoplasm rich in eosinophilic granules. Immunohistochemical staining revealed that all 4 cases were positive for S-100, SOX10, CD68 and Vimentin, and negative for Desmin, MelanA and CK (AE1/AE3), with a Ki-67 proliferation index of ＜5%. All patients underwent complete surgical resection, and no recurrence was observed during the follow-up period of 12-37 months.

Key words: granular cell tumor, cutaneous tumor, pathological diagnosis