Abstract: Transient receptor potential vanilloid 3 (TRPV3) is a non-selective cation channel protein, which is most abundantly expressed in skin keratinocytes, and participates in physiological processes such as keratinocytes proliferation, skin barrier formation, sensory conduction, and hair growth, which plays an important role in maintaining skin homeostasis. Studies have found that TRPV3 plays an important role in the occurrence and development of skin diseases such as atopic dermatitis, Olmsted syndrome, and psoriasis. The role of TRPV3 in the pathogenesis of these skin diseases and its future clinical application were reviewed in this paper.

Key words: atopic dermatitis')">">atopic dermatitis, TRPV3, cation channels, Olmsted syndrome