Abstract: Soluble costimulatory molecules are soluble forms of costimulatory molecules, which participate in the transmission of costimulatory signals and play an important role in self-regulation. Their abnormal expression will affect the body's immune response and the establishment of immune tolerance. It is closely related to the immune regulation, occurrence and development of autoimmune skin diseases. The update of soluble costimulatory molecules in autoimmune cutaneous disease was reviewed in this paper, in order to provide a reference for clinicians and researchers to clarify the pathogenesis and effective treatment of this disease.

Key words: autoimmune cutaneous disease')">">autoimmune cutaneous disease, soluble costimulatory molecules, costimulatory molecules