中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (11): 664-666.doi: 10.12144/zgmfskin201911664

• 论著 • 上一篇    下一篇

寻常型银屑病中DUSP1和DUSP4的表达

孙献琪  栗玉珍   

  1. 哈尔滨医科大学附属第二医院皮肤性病科，哈尔滨，150001
  • 出版日期:2019-11-15 发布日期:2019-11-20
  • 通讯作者: 栗玉珍，E-mail: liyuzhenchina@126.com

The expression of DUSP1 and DUSP4 in psoriasis vulgaris

SUN Xianqi, LI Yuzhen   

  1. Department of Dermatology at the 2nd Affiliated of Harbin Medical University, Harbin 150001, China
  • Online:2019-11-15 Published:2019-11-20
  • Contact: LI Yuzhen，E-mail: liyuzhenchina@ 126.com

PDF (PC)

106

摘要： 目的：检测DUSP1和DUSP4在寻常型银屑病患者皮损的表达水平。方法：Real-time PCR和Western Blot分别检测18例寻常型银屑病皮肤组织和15名正常对照皮肤组织中DUSP1和DUSP4 mRNA及相关蛋白的表达情况。结果：银屑病组DUSP1 mRNA和蛋白的相对表达量分别为0.0939±0.0048和0.5165±0.0254,低于正常对照组的0.2486±0.0060和1.2432±0.3260,差异有统计学意义（Ps＜0.05）。银屑病组DUSP4 mRNA和蛋白的相对表达量为0.3718±0.0370和0.8018±0.0770,与正常对照组比较（0.3645±0.0286和1.3677±0.2287）,差异无统计学意义（Ps＞0.05）。结论：DUSP1表达水平降低可能与寻常型银屑病发生发展有关。

关键词: 寻常型银屑病, DUSP1, MAPK信号通路

Abstract: Objective: To detect the expression level of DUSP1 and DUSP4 in the lesions of psoriasis vulgaris. Methods: The mRNA and protein level of DUSP1 and DUSP4 from 18 psoriasis lesions and 15 normal skin were detected by real-time PCR and Western blot respectively. Results: The levels of mRNA and protein of DUSP1 from psoriasis lesions were (0.0939±0.0048) and (0.5165±0.0254), which were lower than those in the normal skin (0.2486±0.0060 and 1.2432±0.3260), with significant differences (Ps<0.05). There were no significant differences of mRNA and protein of DUSP1 in the psoriasis lesions (0.3718 ±0.0370) and (0.8018 ±0.0770) and normal skin (0.3645±0.0286) and (1.3677±0.2287) (Ps>0.05). Conclusion: The level of DUSP1 in the psoriasis lesions decreases which may be related to the pathogenesis and development of psoriasis vulgaris.

Key words: psoriasis vulgaris, DUSP1, MAPK signaling pathway