中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (1): 8-12.doi: 10.12144/zgmfskin202001008

• 论著 • 上一篇    下一篇

环孢素维持治疗银屑病随机对照研究的文献分析

向志，马一平，宗文凯，崔盘根，陈敏   

  1. 中国医学科学院北京协和医学院皮肤病研究所，南京，210042
  • 出版日期:2020-01-15 发布日期:2020-03-16
  • 通讯作者: 陈敏， E-mail：drchenmin@126.com

Maintenance treatment of cyclosporine in the patients with psoriasis: a systematic review of randomized controlled studies

XIANG Zhi, MA Yiping, ZONG Wenkai, CUI Pangen, CHEN Min   

  1. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2020-01-15 Published:2020-03-16
  • Contact: CHEN Min, E-mail: drchenmin@126.com

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摘要： 检索MEDLINE、Embase、Cochrane图书馆、SinoMed、CNKI和万方数据库中1974年1月1日至2018年7月1日环孢素维持治疗银屑病的随机对照临床研究，评价不同环孢素给药方案治疗银屑病的疗效和安全性。共纳入9篇随机临床对照试验文献，均报道环孢素治疗银屑病有效，其中2篇文献研究发现连续治疗方案在长达24周的维持治疗期内是安全有效的，2篇发现间断治疗比连续治疗更安全有效。

关键词: 环孢素, 银屑病, 维持治疗

Abstract: Related randomized controlled clinical trails from MEDLINE, Embase, Cochrane library, SinoMed, CNKI and wanfang database were searched from Jan 1, 1974 to July 1, 2018. The efficacy and tolerability of different cyclosporine administration protocols for maintenance treatment of psoriasis were evaluated. Nine randomized clinical control trails were reviewed. Generally, cyclosporine was effective and safe for treating psoriasis in all papers. Of nine papers, two reported continuous regimen of cyclosporine was safe within 24 weeks and two reported intermittent treatment was more effective and safe than continuous regimen.

Key words: cyclosporine, psoriasis, maintenance treatment