中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (4): 227-229.doi: 10.12144/zgmfskin202004227

• 病例报告 • 上一篇    下一篇

误诊为系统性红斑狼疮的皮肤型Rosai-Dorfman-Destombes病一例

么艳茹1,王吉波1,张婷2,温大蔚1   

  1. 1青岛大学附属医院风湿免疫科，山东青岛，266003；
    2山东大学齐鲁医院(青岛)风湿科，山东青岛，266035
  • 出版日期:2020-04-15 发布日期:2020-04-27
  • 通讯作者: 王吉波，E-mail：wangjibo2005@126.com

Cutaneous Rosai-Dorfman-Destombes disease misdiagnosed as systemic lupus erythematosus: a case report

YAO Yanru1, WANG Jibo1, ZHANG Ting2, WEN Dawei1   

  1. 1 Department of Rheumatology and Immunology, Affiliated Hospital of Qingdao University, Qingdao 266003,China; 2 Department of Rheumatology, Qilu Hospital of Shandong University (Qingdao), Qingdao 266035, China
  • Online:2020-04-15 Published:2020-04-27
  • Contact: WANG Jibo, E-mail: wangjibo2005@126.com

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摘要： 患者，女，60岁。面部对称性红斑1年，加重伴丘疹、斑块形成6个月。皮肤组织病理检查示：皮肤真皮深层及皮下组织弥漫性淋巴浆细胞浸润，组织细胞增生可见“伸入运动”，免疫组化S-100、CD68阳性，CD1a阴性，给予泼尼松、甲氨蝶呤、沙利度胺治疗2个月后好转。

关键词: Rosai-Dorfman-Destombes病, 皮肤型Rosai-Dorfman-Destombes病, 系统性红斑狼疮

Abstract: A 60-year-old woman presented with progressive erythematous on bilateral face for one year, papules and plaques for 6 months. Skin biopsy showed that large histiocytes exhibited emperipolesis in a background of mixed inflammatory infiltrate in the dermis and subcutaneous tissue. Immunohistochemical stain showed positivity of S-100, CD68 and negativity of CD1a. The skin lesions were improved after prednisone, methotrexate, and thalidomide treatment for two months.

Key words: Rosai-Dorfman-Destombes disease, cutaneous Rosai-Dorfman-Destombes disease, systemic lupus erythematosus