中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (5): 281-285.doi: 10.12144/zgmfskin202105281

• 论著 • 上一篇    下一篇

血清PS-PLA1水平与系统性红斑狼疮疾病活动相关性分析

曾君,李时飞,周小芳,汪婷,宋志强,翟志芳   

  1. 陆军军医大学第一附属医院皮肤科，重庆，400038
  • 出版日期:2021-05-15 发布日期:2021-04-29
  • 通讯作者: 翟志芳，E-mail: zhaizf1004@163.com

Correlation analysis of serum PS-PLA1 level and disease activity of systemic lupus erythematosus

ZENG Jun, LI Shifei, ZHOU Xiaofang, WANG Ting, SONG Zhiqiang, ZHAI Zhifang   

  1. Department of Dermatology, the First Affiliated Hospital of Army Medical University, Chongqing 400038, China
  • Online:2021-05-15 Published:2021-04-29
  • Contact: ZHAI Zhifang, E-mail: zhaizf1004@163.com

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摘要： 目的：探讨磷脂酰丝氨酸-特异性磷脂酶A1(PS-PLA1)与系统性红斑狼疮(SLE)疾病活动的相关性。方法：收集SLE患者及健康对照，对患者进行SLEDAI评分，采用酶联免疫吸附法（ELISA）测定两组血清中PS-PLA1表达水平，分析PS-PLA1与SLE疾病活动的相关性。结果：共收集SLE患者101例（活动组70例，稳定组31例），健康对照组85例。SLE患者血清中PS-PLA1表达（35.555±10.098）ng/mL明显高于健康对照组（26.416±9.785)ng/mL(P<0.001)，活动组PS-PLA1表达（38.222±9.752）ng/mL明显高于稳定组（29.532±8.194）ng/mL（P<0.001）。患者血清中PS-PLA1与SLEDAI评分、抗dsDNA抗体以及C反应蛋白（CRP）呈正相关（均P<0.05），与C3、C4水平呈负相关（P<0.05）。PS-PLA1作为SLE标志物预测疾病活动敏感性为80.0%，特异性为66.7%。结论：SLE患者血清中PS-PLA1明显升高，表达水平与SLE疾病活动呈正相关。

关键词: 系统性红斑狼疮, 磷脂酰丝氨酸-特异性磷脂酶A1, SLEDAI评分, 疾病活动

Abstract: Objective: To investigate the correlation of phosphatidylserine-specific phospholipase A1 (PS-PLA1) and the disease activity in the patients with systemic lupus erythematosus (SLE). Methods: The expression level of PS-PLA1 in serum of SLE patients and healthy controls was detected by enzyme-linked immunosorbent assay (ELISA). Disease activity was assessed using SLEDAI score. The correlation between PS-PLA1 level and SLE activity was analyzed. Results: A total of 101 SLE patients (31 in activity group and 70 in stability group) and 80 healthy controls were enrolled. The expression level of PS-PLA1 in SLE patients (35.555±10.098) ng/mL was significantly higher than that in healthy controls (26.416±9.785) ng/mL (P<0.001), and the expression level of PS-PLA1 in active group (38.222±9.752) ng/mL was significantly higher than that in stable group (29.532±8.194) ng/mL (P<0.001). The level of PS-PLA1 was positively correlated with SLEDAI score, anti-dsDNA antibody and C-reactive protein (P<0.05), and negatively correlated with C3 and C4 (P<0.05). The sensitivity and specificity of PS-PLA1 as a marker of SLE activity were 80.0% and 66.7% respectively. Conclusion: The serum level of PS-PLA1 in SLE patients is increased, which is positively correlated with disease activity.

Key words: systemic lupus erythematosus, PS-PLA1, SLEDAI score, disease activity