中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (5): 316-320.doi: 10.12144/zgmfskin202005316

• 综述 • 上一篇    

全反式维甲酸对银屑病角质形成细胞间隙连接通信的影响

梁晓冬1,邓新华1,李春红1,梁景耀2,张锡宝2   

  1. 1暨南大学附属顺德医院，佛山，528305；2广州医科大学皮肤病研究所/广州市皮肤病防治所，广州，510095
  • 出版日期:2020-05-15 发布日期:2020-05-28
  • 通讯作者: 张锡宝，E-mail: zxibao@126.com

Update of the effect of all-trans retinoic acid on gap junctional intercellular communication of keratinocytes in psoriasis

LIANG Xiaodong1, DENG Xinhua1, LI Chunhong1, LIANG Jingyao2, ZHANG Xibao2   

  1. 1 The Affiliated Shunde Hospital of Jinan University, Foshan 528305, China; 2 Institute of Dermatology, Guangzhou Medical University/Guangzhou Institute of Dermatology, Guangzhou 510095,China
  • Online:2020-05-15 Published:2020-05-28
  • Contact: ZHANG Xibao, E-mail: zxibao@126.com

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摘要： 细胞中的间隙连接通信（GJIC）是在多细胞生物体中普遍存在的通信模式，其功能由连接蛋白（Cx）实现，目前有关连接蛋白43（Cx43）的研究较多，并显示了与银屑病的相关性。全反式维甲酸（ATRA）可影响银屑病角质形成细胞间GJIC功能，本文就全反式维甲酸对银屑病角质形成细胞间隙连接通信的影响进行综述。

关键词: ATRA, GJIC, 银屑病, Cx43, IL-22

Abstract: Gap junctional intercellular communication (GJIC) is the ubiquitous communication mode in multicellular organisms and the function is achieved by connexin (Cx). A few of studies have showed the correlations between connexin 43 (Cx43) and psoriasis. The all-trans retinoic acid (ATRA) may affect the GJIC function of psoriatic keratinocytes. The effect of all-trans retinoic acid on gap junctional intercellular communication of keratinocytes in psoriasis is reviewed in this paper.

Key words: ATRA, GJIC, psoriasis, Cx43, IL-22