中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (6): 378-381.doi: 10.12144/zgmfskin202006378

• 综述 • 上一篇    下一篇

甲氨蝶呤在皮肤科的应用

叶瑞贤,刘焕颜,熊绮颖,董良娇,徐晓,张锡宝   

  1. 广州医科大学皮肤病研究所,广州市皮肤病防治所,广州,510095
  • 出版日期:2020-06-15 发布日期:2020-06-05
  • 通讯作者: 徐晓,E-mail:38147311@qq.com

Application of methotrexate in dermatology

YE Ruixian, LIU Huanyan, XIONG Qiying, DONG Liangjiao, XU Xiao, ZHANG Xibao   

  1. Guangzhou Medical University Dermatology Institute, Guangzhou Institute of Dermatology, Guangzhou 510095, China
  • Online:2020-06-15 Published:2020-06-05
  • Contact: XU Xiao, E-mail: 38147311@qq.com

摘要: 甲氨蝶呤是一种叶酸拮抗剂,具有抗增殖、抗炎、免疫抑制的作用,目前被广泛应用于多种皮肤病的治疗,其毒副作用主要包括骨髓抑制、肝毒性、肺毒性、肾毒性等。本文就甲氨蝶呤在皮肤科的应用及毒副作用进行了综述。

关键词: 甲氨蝶呤, 皮肤科, 应用

Abstract: Methotrexate (MTX) is a kind of folic acid antagonist with anti-proliferation, anti-inflammatory, and immunological inhibition effects. It has been widely used in the treatment of various skin diseases. The adverse reactions mainly include bone marrow suppression, hepatotoxicity, and pulmonary and renal toxicity, etc. The application of MTX in dermatology and adverse reactions are reviewed in this paper.

Key words: methotrexate, dermatology, application