中国麻风皮肤病杂志 ›› 2019, Vol. 35 ›› Issue (2): 65-69.doi: 10.12144/zgmfskin201902065

• 论著 •    下一篇

麻风生物样本库的建立和应用

王真真1,2,3  刘红1,2,3  王川1,2,3  于功奇1,2,3  付希安1,2,3  暴芳芳1,2,3#br# 孙勇虎1,2,3  糜自豪1,2,3  孙乐乐1,2,3  潘晴1,2,3  初同胜1,2  周桂芝1,2#br# 熊立4  杨军4  杨荣德4  李进岚5  柯伟5  宁湧6  熊俊浩6#br# 黎明7  熊明洲7  杨斌7  段启志8  王宏8  李伟8  旷燕飞9#br# 李俊华9  王腊梅10  操秋阳10  肖鹏11  肖邦忠11  张连华12  蔺兆星13#br# 王耀斐13  沈云良14  严丽英14  武文斌15  郑虎16  占先发17  李旺华17#br# 尚修建18  许玉军19  刘巧19  严良斌20  张国成20  陈树民1,2  张福仁1,2,3,21,22#br#   

  1. 1山东省皮肤病性病防治研究所，山东省医学科学院，济南，250022
    2山东省皮肤病医院，济南，250022
    3山东省皮肤性病学重点实验室，济南，250022
    4云南省疾病预防控制中心，昆明，650100
    5贵州省疾病预防控制中心，贵阳，550004
    6四川省皮肤病性病防治研究所，成都，610014
    7广东省皮肤病防治研究所，广州，510098
    8广西壮族自治区皮肤病防治研究所，南宁，530000
    9湖南省疾病预防控制中心，长沙，410005
    10江西省寄生虫病防治研究所，南昌，330046
    11重庆市疾病预防控制中心，重庆，400042
    12江苏省疾病预防控制中心，南京，210009
    13陕西省地方病防治研究所，西安，710003
    14浙江省皮肤病防治研究所，湖州，313200
    15福建省疾病预防控制中心，福州，350001
    16安徽省皮肤病防治研究所，合肥，230000  17湖北省疾病预防控制中心，武汉，430079  18新疆维吾尔自治区疾病预防控制中心，乌鲁木齐，830001  19海南省皮肤病性病防治中心，海口，571199 20中国医学科学院皮肤病研究所，南京，210042  21山东大学医学院，济南，250000  22济南大学山东省医学科学院，济南，250000
  • 出版日期:2019-02-20 发布日期:2019-03-07
  • 通讯作者: 张福仁，E-mail: zhangfuren@hotmail.com

The establishment and application of leprosy biobank

WANG Zhenzhen1,2,3，LIU Hong1,2,3，WANG Chuan1,2,3，YU Gongqi1,2,3，FU Xi'an1,2,3，BAO Fangfang1,2,3，SUN Yonghu1,2,3，MI Zihao1,2,3，SUN Lele1,2,3，PAN Qing1,2,3，CHU Tongsheng1,2，ZHOU Guizhi1,2，XIONG Li4，YANG Jun4，YANG Rongde4，LI Jinlan5，KE Wei5，NING Yong6，XIONG Junhao6，LI Ming7，XIONG Mingzhou7，YANG Bin7，DUAN Qizhi8，WANG Hong8，LI Wei8，KUANG Yanfei9，LI Junhua9，WANG Lamei10，CAO Qiuyang10，XIAO Peng11，XIAO Bangzhong11，ZHANG Lianhua12，LIN Zhaoxing13，WANG Yaofei13，SHEN Yunliang14，YAN Liying14，WU Wenbin15，ZHENG Hu16，ZHAN Xianfa17，LI Wanghua17，SHANG Xiujian18，XU Yujun19，LIU Qiao19，YAN Liangbin20，ZHANG Guocheng20，CHEN Shumin1,2，ZHANG Furen1,2,3,21,22   

  1. 1. Shandong Provincial Institute of Dermatology and Venereology, Jinan 250022, China; 
    2. Shandong Provincial Hospital for Skin Diseases, Shandong University, Jinan 250022, China; 
    3. Shandong Provincial Key Lab for Dermatovenereology, Jinan 250022, China; 
    4. Yunnan Provincial Center for Disease Control and Prevention, Kunming 650100, China; 
    5. Guizhou Provincial Center for Disease Control and Prevention, Guiyang 550004, China; 
    6. Sichuan Provincial Institute of Dermatology, Chengdu 610014, China; 
    7. Guangdong Provincial Institute of Dermatology, Guangzhou 510098, China; 
    8. Guangxi Provincial Institute of Dermatology, Nanning 530000, China; 
    9. Hunan Provincial Center for Disease Control and Prevention, Changsha 410005, China; 
    10. Jiangxi Provincial Institute of Parasitic Diseases, Nanchang 330046, China; 
    11. Chongqing Center for Disease Control and Prevention, Chongqing 400042, China; 
    12. Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China; 
    13. Shanxi Provincial Institute for Endemic Disease Control, Xian 710003, China; 
    14. Zhejiang Provincial Institute of Dermatology, Huzhou 313200, China; 
    15. Fujian Center for Disease Control and Prevention, Fuzhou 350001, China; 
    16. Anhui Provincial Institute of Dermatology, Hefei 230000, China;  17. Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China;  18. Xinjiang Center for Disease Control and Prevention, Urumchi 830001, China;   19. Hainan Provincial Center for Skin Disease and STI Control, Haikou 571199, China;   20. Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China; 21. School of Medicine, Shandong University, Jinan 250000, China;  22. University of Jinan, Shandong Academy of Medical Science, Jinan 250000, China
  • Online:2019-02-20 Published:2019-03-07
  • Contact: ZHANG Furen, E-mail: zhangfuren@hotmail.com

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摘要： 目的：建立麻风生物样本库，为解决“消除麻风危害”的关键科学问题提供生物资源。方法：山东省建立项目实施小组，协同相关省市麻风防治工作人员核实完善所在区域麻风患者临床信息，采集患者血液、组织等样本，然后采用相关技术处理各类生物标本，完成入库的同时将临床信息录入生物样本库管理系统。结果：自2005年建库以来，共收集到来自全国19个省份、19个民族的81,532份不同类型样本，其中组织标本35,268份，血液标本33,320份，微生物标本（鼻黏膜拭子）12,944份；以上述样本为基础开展了麻风的系列研究并取得原创性成果。结论：建成了国际上最大的麻风生物资源库，以资源库为基础开展国内外合作并取得一系列原创成果，为完成我国“消除麻风危害中长期规划（2011-2020）”，进而为实现世界卫生组织“创造一个没有麻风的世界”贡献中国智慧奠定了基础。

关键词: 麻风, 生物样本库, 应用

Abstract: Objective: To establish a biobank for leprosy and provide biological resources for solving the key scientific problems of "eliminating leprosy hazard". Methods: We collected blood and tissue samples with the help of leprosy prevention staff from each provinces. All kinds of samples were extracted by using the related technologies, and then imported the data into the biobank management system and stored the samples into the biobank. Results: The preparing work of biobank began in 2005. As of Feb 28, 2017, 81,532 samples (including both Han and 18 ethnic minorities) from 19 provinces have been collected, covering 35,268 tissue samples, 33,320 blood samples and 12,944 microbiological specimens (Nasal swab). Based on these resource, our team conducted a series research initiatives involving genetic background of leprosy and risk factor of dapsone hypersensitivity syndrome as well. Conclusion: The largest leprosy Biobank in the world has been successfully established which makes our team has achieved original findings in leprosy research and in order to complete China's long-term plan for the elimination of leprosy (2011-2020), also it has laid the foundation for the world health organization to contribute Chinese wisdom to "creating a world free of leprosy".

Key words: leprosy, biobank, application