中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (8): 540-541.doi: 10.12144/zgmfskin202208540

• 临床研究 • 上一篇    下一篇

大剂量甲氨蝶呤成功治疗重症关节病型银屑病一例

孙勇虎,曹珊,赵晴,李建可,王秀环,张福仁   

  1. 山东第一医科大学附属皮肤病医院(山东省皮肤病医院)，山东省皮肤病性病防治研究所，济南，250022
  • 出版日期:2022-08-15 发布日期:2022-06-22

High dose methotrexate successfully treated severe arthropathic psoriasis: a case report

SUN Yonghu, CAO Shan, ZHAO Qing, LI Jianke, WANG Xiuhuan, ZHANG Furen   

  1. Shandong Provincial Hospital for Skin Diseases & Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan 250022, China
  • Online:2022-08-15 Published:2022-06-22

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摘要： 甲氨蝶呤是关节病型银屑病的一线药物，但患者存在治疗敏感性和耐受度的差异，本文报道一例甲氨蝶呤低敏感性重症关节病型银屑病的治疗过程，起效剂量达40 mg qw，控制病情后加用TNF-α抑制剂维持并减量，随访36周报道其治疗情况。

关键词: 关节病型银屑病, 甲氨蝶呤, 药物低敏感性

Abstract: Methotrexate is first-line drugs in patients with Psoriatic arthritis (PsA). However, the patients differ from treatment sensitivity and tolerance. Here we report a PsA patient with low sensitivity successfully treated with high dose methotrexate. The effective dose is up to 40 mg, once a week. After controlled the condition, TNF-α inhibitor was given additionally. The dose of MTX was gradually reduced to 20mg once a week. We followed 36 weeks and the patient's condition is stable with no joint pain.

Key words: psoriatic arthritis, methotrexate, drug hyposensitivity