中国麻风皮肤病杂志 ›› 2020, Vol. 36 ›› Issue (10): 636-640.doi: 10.12144/zgmfskin202010636

• 综述 • 上一篇    

关节病型银屑病生物标志物研究进展

王怡怡1,李高洁1,兰小梦2,陈泽镕2,李薇1   

  1. 1四川大学华西医院皮肤性病科，成都，610041；
    2四川大学华西公共卫生学院，成都，610041
  • 出版日期:2020-10-15 发布日期:2020-09-24
  • 通讯作者: 李薇，E-mail: liwei476@wchscu.cn

Update of biomarkers in psoriatic arthritis

WANG Yiyi1, LI Gaojie1, LAN Xiaomeng2, CHEN Zerong2, LI Wei1   

  1. 1 Department of Dermatovenereology, West China Hospital, Sichuan University, Chengdu 610041, China; 2 West China School of Public Health, Sichuan University, Chengdu 610041, China
  • Online:2020-10-15 Published:2020-09-24
  • Contact: LI Wei, E-mail: liwei476@wchscu.cn

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摘要： 生物标志物在关节病型银屑病（PsA）的发病机制中扮演了重要角色，包括调控T细胞、NK细胞、调节细胞增殖分化等，临床上可作为疾病诊断、活动度判断、临床分型、治疗反应的标志物。本文就可溶性生物标志物、细胞生物标志物、遗传生物标志物对PsA发病机制的研究进展进行了综述。

关键词: 银屑病, 关节病型银屑病, 生物标志物

Abstract: It has been found that biomarkers play an important role in the pathogenesis of psoriatic arthritis (PsA) in recent years such as regulating T cells, NK cells, and the proliferation and differentiation of cells. Biomarkers can be used as markers for psoriatic arthritis diagnosis, disease activity, clinical typing and treatment response. The update of soluble biomarkers, cell biomarkers and genetic biomarkers in the pathogenesis of PsA is reviewed in this paper.

Key words: psoriasis, psoriatic arthritis, biomarker