中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (3): 180-184.doi: 10.12144/zgmfskin202103180

• 综述 • 上一篇    下一篇

氨甲环酸在皮肤科的应用进展

唐文,陈爱军   

  1. 重庆医科大学附属第一医院皮肤科, 重庆, 400016
  • 出版日期:2021-03-15 发布日期:2021-03-03
  • 通讯作者: 陈爱军，E-mail：cajhx@aliyun.com

Update of tranexamic acid in dermatology

TANG Wen, CHEN Aijun   

  1. Department of Dermatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016,China
  • Online:2021-03-15 Published:2021-03-03
  • Contact: CHEN Aijun, E-mail: cajhx@aliyun.com

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摘要： 氨甲环酸是一种常见的抗纤溶药物，目前广泛用于血友病患者拔牙术后止血、其他外科手术或急性创伤止血、月经过多等疾病。越来越多地研究表明它不仅具有抗继发性纤溶作用，还具有抑制血管生成、减少黑色素生成、抗炎、抗变态反应、抗皮肤自然衰老和光老化作用。在皮肤科领域，氨甲环酸对黄褐斑、炎症后色素沉着、Riehl黑变病等多种疾病具有治疗作用。本文对氨甲环酸在皮肤疾病中的作用机制、疗效、不良反应及安全性进行综述。

关键词: 氨甲环酸, 黄褐斑, 皮肤疾病

Abstract: Tranexamic acid is a common antifibrinolytic drug, which is widely used in hemophilia patients after tooth extraction to stop bleeding, other surgical operations or acute trauma hemostasis, menorrhagia and other diseases. More and more studies have demonstrated that it not only has the effect of anti-secondary fibrinolysis, but also has the effects of anti-angiogenesis, inhibiting melanin synthesis, anti-inflammation, anti-allergy, improving skin natural aging and photoaging. Tranexamic acid has a therapeutic effect on many kinds of dermatosis, such as melasma, post-inflammatory hyperpigmentation, Riehl's melanosis, etc. The mechanism of action, efficacy, adverse reactions and safety of tranexamic acid in the treatment of skin diseases is reviewed in this paper.

Key words: tranexamic acid, melasma, skin diseases