中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (1): 14-20.doi: 10.12144/zgmfskin202201014

• 论著 • 上一篇    下一篇

皮肌炎伴钙质沉着一例并国内外105例回顾分析

李登丽1,郑海雁1,史冬梅1,2   

  1. 1济宁市第一人民医院皮肤科，山东济宁，272001；
    2济宁市第一人民医院医学真菌实验室，山东济宁，272001
  • 出版日期:2022-01-15 发布日期:2021-11-01
  • 通讯作者: 史冬梅，E-mail：shidongmei28@163.com

A case report of calcinosis in dermatomyositis and a retrospective analysis of 105 cases in domestic and foreign literatures

LI Dengli1, ZHENG Haiyan1, SHI Dongmei1,2   

  1. 1 Department of Dermatology, Jining No. 1 People's Hospital, Jining 272001, China; 
    2 Laboratory of Medical Mycology, Jining No. 1 People's Hospital, Jining 272001, China
  • Online:2022-01-15 Published:2021-11-01
  • Contact: SHI Dongmei, E-mail: shidongmei28@163.com

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摘要： 报道1例皮肌炎伴钙质沉着并总结相关文献。共分析总结105例皮肌炎伴钙质沉着患者，其中女59例，男46例，1~12岁患者最多，21%的患者皮损局限，以臀部、四肢为主。除典型结节、斑块外，3.8%的患者可形成钙性液体或钙化性囊性病灶，14.3%患者伴严重关节挛缩、畸形。皮肌炎伴钙质沉着多有危险因素，如持续活动性炎症反应、局部隐性损伤、抗NXP-2抗体阳性等。患者多采用多种药物联合，或者药物与外科手术联合治疗。TNF-α抑制剂等生物制剂正逐步应用于临床个案治疗。

关键词: 皮肌炎, 钙质沉着

Abstract: We report a case of calcinosis in dermatomyositis (DM) and review the literature of calcinosis in DM. The clinical data of 105 patients with calcinosis in dermatomyositis reported before was reviewed. Of 105 patients, 59 were female and 46 were male. The peak age was 1-12 years. The lesions limited to individual existing lesions in 21% patients and the most common site was buttocks and limbs. Typical nodules and plaques are the most common lesions and 3.8% patients had calcified fluid or calcified cystic lesions, and 14.3% had severe joint contracture and deformity. The risks for calcinosis in dermatomyositis included prolonged active inflammation, local invisible injury, and positive anti-NXP-2 antibody. Various therapies have been used for calcinosis in DM, such as a combination of different drugs, and drugs combination with surgical removal of the calcium deposits. TNF-ɑ inhibitors have been tried in a few case reports.

Key words: dermatomyositis, calcinosis