中国麻风皮肤病杂志 ›› 2022, Vol. 38 ›› Issue (3): 195-198.doi: 10.12144/zgmfskin202203195

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前列腺素F2α衍生物在皮肤科的应用

刘泠汐,金双,陈崑   

  1. 中国医学科学院 北京协和医学院 皮肤病医院理疗科，南京，210042

  • 出版日期:2022-03-15 发布日期:2022-01-06
  • 通讯作者: 陈崑，E-mail: kunchen181@aliyun.com

Application of prostaglandin F2ɑ analogs in dermatology

LIU Lingxi, JIN Shuang, CHEN Kun   

  1. Department of Physical Therapy, Hospital for Skin Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing 210042, China
  • Online:2022-03-15 Published:2022-01-06
  • Contact: CHEN Kun, E-mail: kunchen181@aliyun.com

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摘要： PF2α衍生物在眼科主要用于治疗开角型青光眼，其常见的不良反应有多毛症和皮肤色素沉着。因此，目前许多研究将PF2α衍生物应用于脱发和色素减退性疾病的治疗，主要包括雄激素性脱发、斑秃、化疗后脱发、白癜风以及炎症后色素减退。

关键词: 前列腺素F2α衍生物, 比马前列素, 拉坦前列素, 斑秃, 雄激素性脱发, 白癜风

Abstract: Prostaglandin F2a analogs, commonly prescribed for glaucoma treatment in ophthalmology, have been reported to induce adverse reactions such as cutaneous hypertrichosis and hyperpigmentation. Therefore, it have been applied to treat alopecia and disorders of hypopigmentation, mainly contains androgenic alopecia, alopecia areata, chemotherapy-induced alopecia, vitiligo, and postinflammatory hypopigmentation.

Key words: prostaglandin F2ɑ analog, bimatoprost, latanoprost, alopecia areata, androgenic alopecia, vitiligo