中国麻风皮肤病杂志 ›› 2021, Vol. 37 ›› Issue (4): 256-259.doi: 10.12144/zgmfskin202104256

• 综述 • 上一篇    下一篇

白癜风动物模型研究进展

黄新绿,杜娟,徐前喜,王芳,李曼,张艳坤,丁晓岚   

  1. 北京大学人民医院皮肤科，北京，100044
  • 出版日期:2021-04-15 发布日期:2021-04-07
  • 通讯作者: 丁晓岚，E-mail: Lancyding@126.com

Update of animal models of vitiligo

HUANG Xinlyu, DU Juan, XU Qianxi, WANG Fang, LI Man, ZHANG Yankun, DING Xiaolan    

  1. Department of Dermatology, Peking University People's Hospital, Beijing 100044, China
  • Online:2021-04-15 Published:2021-04-07
  • Contact: DING Xiaolan, E-mail: Lancyding@126.com

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摘要： 白癜风的病因和发病机制尚未完全阐明，遗传、自身免疫、氧化应激和环境等多种因素参与了白癜风的发病, 建立适宜的白癜风动物模型可为研究其发病机制和开发新疗法奠定基础。相较自发性白癜风模型，诱导性模型能更好的模拟白癜风发病的病理过程及影响因素。本文着重综述了诱导性白癜风动物模型的最新进展。

关键词: 白癜风, 动物模型, 诱导性白癜风模型

Abstract: The etiology and pathogenesis of vitiligo has not been fully clarified, which involves  genetics, autoimmune mechanisms, oxidative stress and environmental factors. Suitable animal models are the bases of pathogenesis study. Compared with the spontaneous vitiligo models, induced vitiligo models can be more capable to simulate the pathogenesis and influencing factors of vitiligo. The update of  vitiligo animal models is reviewed in this paper.

Key words: vitiligo, animal model, induced vitiligo model